Below you will find a list of player-submitted optimized layouts for solving different portions of the production pipeline in DSP. If you have a layout you'd like to submit, go ahead and add it!
Discord/Steam user Falk has created a guide on Steam with several great layouts:
Production Line Spreadsheet
This Google Sheet (currently incomplete) helps you plan the structures and ratios necessary to produce various elements in the game. To use, select "Make a copy" from the file menu after opening.
The Conveyor Belt Mk.I can carry 6 items per second or 360 items per minute. A Mining Machine that is covering exactly 6 veins will produce 180 items per second. Combining the belts from two mining machines will fully saturate a Conveyor Belt Mk.I with a full 360 items per minute. Note: Mining machines can cover the same resource veins, as shown in the picture below.
Reddit user u/oldshavingfoam has created a number of excellent layouts.